Recently saw the following video by Chris Marino dealing with Rarevision's free 5DtoRGB plugin that transcodes your h.264 MOV files from DSLRs so that they can better be color corrected.
A free plugin? Yes, I'll take it!
After transcoding a h.264 MOV file into uncompressed 10-bit with the plugin, I put it through a basic trial test, here below.
Well, the file was originally about 300 MB. Uncompressed it was 12.5 GB.
The artifacts were almost negligible at best. Of course, I was doing only basic color correcting, and no effects were done to the video footage. I'm sure the compressed file will fall apart more the more that is done to it. To be sure, I'll do some more tests later. But here is the first round.